Trifluoroacetic acid → 1-(1-cyclopropyl-1-methoxypropan-2-yl)-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid

HRID 2206598Notes

Reaction equation

[CH:1]1([CH:4]([O:24][CH3:25])[CH:5]([N:7]2[C:11]3=[N:12][CH:13]=[CH:14][CH:15]=[C:10]3[C:9]([C:16]([O:18]C(C)(C)C)=[O:17])=[C:8]2[CH3:23])[CH3:6])[CH2:3][CH2:2]1.C(C(O)=O)(F)(F)F>C(Cl)Cl>[CH:1]1([CH:4]([O:24][CH3:25])[CH:5]([N:7]2[C:11]3=[N:12][CH:13]=[CH:14][CH:15]=[C:10]3[C:9]([C:16]([OH:18])=[O:17])=[C:8]2[CH3:23])[CH3:6])[CH2:3][CH2:2]1

Participants

Conditions

Temperature: 25 °C

Procedure

To a solution of tert-butyl 1-(1-cyclopropyl-1-methoxypropan-2-yl)-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylate (100 mg, 0.29 mmol) in CH2Cl2 (2 mL) were added CF3CO2H (2 mL). The solution was stirred at 25° C. for 2 h. After the reaction completed, the solution was concentrated under reduced pressure to obtain 1-(1-cyclopropyl-1-methoxypropan-2-yl)-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid as red oil. (87 mg, yield 99%).

Workup

concentrationthe solution was concentrated under reduced pressure

Sources & evidence

ORD record: ord-90c2005c6c144e75a9d04ea1eb50bc39
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09371331B2

Reaction notes

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