2-Amino-6-methyl-4-oxo-4H-pyran-3-carbonitrile → HCID 178429083, compound

HRID 2206607Notes

Reaction equation

HRID 2206607 reaction equation
[NH2:1][C:2]1[O:3][C:4]([CH3:11])=[CH:5][C:6](=[O:10])[C:7]=1[C:8]#[N:9]>Cl.O>[OH:3][C:2]1[N:1]=[C:4]([CH3:11])[CH:5]=[C:6]([OH:10])[C:7]=1[C:8]#[N:9]

Participants

3

Reactant 1

HCID 114805352-Amino-6-methyl-4-oxo-4H-pyran-3-carbonitrile

Product 1

HCID 178429083HCID 178429083, compoundYield 66%

Reagents, catalysts & solvents 1

HCID 21885828Hydrate;hydrochlorideSolvent

Procedure

2-amino-6-methyl-4-oxo-4H-pyran-3-carbonitrile from above was dissolved in 4 N HCl/H2O (2500 ml) and refluxed for 5 h with stirring strongly. After cooled to r.t., the precipitate was filtered, washed with H2O (500 ml), ethanol (500 ml) and MTBE (200 ml) and dried under high vacuum. 2,4-dihydroxy-6-methylnicotinonitrile was obtained as a yellow powder. (165 g, yield 66%).

Workup

  1. temperaturerefluxed for 5 h
  2. filtrationthe precipitate was filtered
  3. washwashed with H2O (500 ml), ethanol (500 ml) and MTBE (200 ml)
  4. customdried under high vacuum

Sources & evidence

ORD record
ord-f1470a54b9f94cd7aa967b5c7732f082
Source dataset
uspto-grants-2016_06
Patent number
US09371331B2

Reaction notes

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