HCID 117804505, compound → HCID 117779091, compound

HRID 2206616Notes

Reaction equation

HRID 2206616 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[C:10]([O:20]C)=[N:11][C:12]([CH3:19])=[CH:13][C:14]=1[O:15][CH:16]([F:18])[F:17])(C)(C)C>Cl>[NH2:7][CH2:8][C:9]1[C:10](=[O:20])[NH:11][C:12]([CH3:19])=[CH:13][C:14]=1[O:15][CH:16]([F:17])[F:18]

Participants

3

Reactant 1

HCID 117804505HCID 117804505, compound

Product 1

HCID 117779091HCID 117779091, compoundYield 80.8%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

To a solution of tert-butyl((4-(difluoromethoxy)-2-methoxy-6-methylpyridin-3-yl)methyl)carbamate (830 mg, 2.61 mmol) in HCl (10 mL) was stirred at 100° C. for 1.5 hours under N2. The mixture was concentrated to afford 3-(aminomethyl)-4-(difluoromethoxy)-6-methylpyridin-2(1H)-one (430 mg, yellow solid, 80.8% yield). LCMS (M+H+) m/z: calcd 204.07. found 205.0. 1H NMR (400 MHz, DMSO): δ 7.621-7.258 (t, 1H), 6.26 (s, 1H), 3.837-3.822 (d, J=6.0 Hz, 2H)

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-e3009f7a87574f34a791769f5c3bd464
Source dataset
uspto-grants-2016_06
Patent number
US09371331B2

Reaction notes

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