HCID 10703244, compound → HCID 12915443, compound

HRID 2206633Notes

Reaction equation

HRID 2206633 reaction equation
[CH:1]([C:3]1[NH:4][C:5]2[C:10]([C:11]=1[C:12]([O:14][CH3:15])=[O:13])=[CH:9][CH:8]=[CH:7][CH:6]=2)=[CH2:2]>[Pd].CO>[CH2:1]([C:3]1[NH:4][C:5]2[C:10]([C:11]=1[C:12]([O:14][CH3:15])=[O:13])=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH3:2]

Participants

4

Reactant 1

HCID 10703244HCID 10703244, compound

Product 1

HCID 12915443HCID 12915443, compoundYield 99%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Methyl 2-vinyl-1H-indole-3-carboxylate (80 mg, 0.4 mmol) and 10% palladium on charcoal (100 mg) in methanol (30 mL) were stirred under hydrogen 0.2 MPa at room temperature for 15 hours. The mixture was filterated the solid and concentrated in vacuum to obtain methyl 2-ethyl-1H-indole-3-carboxylate as a white solid (79 mg, 99%) LRMS (M+H+) m/z: calcd 203.1 found 203.

Workup

  1. concentrationconcentrated in vacuum

Sources & evidence

ORD record
ord-203afddc55f74a9c9c0a0bcc1443ef45
Source dataset
uspto-grants-2016_06
Patent number
US09371331B2

Reaction notes

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