Hydrochloric Acid → 2-Amino-2-(3-chloro-2-fluorophenyl)ethan-1-ol hydrochloride

HRID 220677Notes

Reaction equation

HRID 220677 reaction equation
[Cl:1][C:2]1[C:3]([F:19])=[C:4]([CH:8]([NH:11]C(=O)OC(C)(C)C)[CH2:9][OH:10])[CH:5]=[CH:6][CH:7]=1.Cl>ClCCl.O1CCOCC1>[ClH:1].[NH2:11][CH:8]([C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[C:3]=1[F:19])[CH2:9][OH:10]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 59536935HCID 59536935, compound

Product 1

HCID 666721262-Amino-2-(3-chloro-2-fluorophenyl)ethan-1-ol hydrochloride

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

Of the compound from Example 160A, 1.74 g (6.01 mmol) were introduced in 20 ml of dichloromethane. A quantity of 22 ml (88.00 mmol) of 4M hydrogen chloride in dioxane was added. After stirring at RT for 1 h, the reaction mixture was evaporated to dryness on a rotary evaporator and dried in an HV. This gave 1.38 g (88% of theory) of the title compound in approximately 87% purity.

Workup

  1. customthe reaction mixture was evaporated to dryness on a rotary evaporator
  2. customdried in an HV

Sources & evidence

ORD record
ord-333d01dbbc8c444a9689b08d7da164ec
Source dataset
uspto-grants-2012_06
Patent number
US08202895B2

Reaction notes

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