Hydrochloric Acid → HCID 66672055, compound

HRID 220687Notes

Reaction equation

HRID 220687 reaction equation
[OH:1][CH2:2][CH2:3][CH:4]([NH:13]C(=O)OC(C)(C)C)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[O:11][CH3:12].[ClH:21]>ClCCl.O1CCOCC1>[ClH:21].[NH2:13][CH:4]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[O:11][CH3:12])[CH2:3][CH2:2][OH:1]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 59536731HCID 59536731, compound

Product 1

HCID 66672055HCID 66672055, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

Of the compound from Example 172A, 100 mg (0.36 mmol) were dissolved in 2 ml of dichloromethane, and 1.63 ml (6.52 mmol) of a 4M solution of hydrogen chloride in dioxane were added. The yellow solution was subsequently stirred at RT for 1 h. The reaction mixture was evaporated to dryness on a rotary evaporator and dried in an HV. This gave 88 mg (100% of theory) of the title compound.

Workup

  1. customThe reaction mixture was evaporated to dryness on a rotary evaporator
  2. customdried in an HV

Sources & evidence

ORD record
ord-8750fcfcf7324e35a1aec583d45328b9
Source dataset
uspto-grants-2012_06
Patent number
US08202895B2

Reaction notes

Loading…