HCID 86680281, compound → HCID 86680280, compound

HRID 2206887Notes

Reaction equation

HRID 2206887 reaction equation
[F:1][C:2]([F:32])([F:31])[C:3]1[CH:4]=[CH:5][C:6]2[C:10]([Cl:11])=[C:9]([C:12]([N:14]3[CH2:17][CH:16]([N:18]4[CH2:23][CH2:22][N:21](C(=O)C(F)(F)F)[CH2:20][CH2:19]4)[CH2:15]3)=[O:13])[S:8][C:7]=2[CH:30]=1>CCN(CC)CC.CO>[Cl:11][C:10]1[C:6]2[CH:5]=[CH:4][C:3]([C:2]([F:32])([F:1])[F:31])=[CH:30][C:7]=2[S:8][C:9]=1[C:12]([N:14]1[CH2:17][CH:16]([N:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[CH2:15]1)=[O:13]

Participants

4

Reactant 1

HCID 86680281HCID 86680281, compound

Product 1

HCID 86680280HCID 86680280, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8471TriethylamineSolvent

Procedure

A solution of compound 1c (0.30 g, 0.60 mmol) in Et3N (1 mL) and MeOH (9 mL) was stirred at room temperature for 3 days. It was then concentrated to give compound 1d, which was used in the next reaction without further purification.

Workup

  1. concentrationIt was then concentrated

Sources & evidence

ORD record
ord-f51163f4eb7746378d7c0797d175b345
Source dataset
uspto-grants-2016_06
Patent number
US09375430B2

Reaction notes

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