反应详情

Of the compound from Example 76A, 1.2 g (3.32 mmol), 150 mg of platinum on carbon (5%) and 150 ml of methanol were hydrogenated under standard hydrogen pressure. For work-up, the catalyst was filtered off and the filtrate was concentrated on a rotary evaporator. The crude product was purified by preparative HPLC (Method 20). The product fractions were combined and freed from the solvent on a rotary evaporator. Drying in an HV gave 890 mg (73% of theory) of the title compound.

1. filtrationFor work-up, the catalyst was filtered off
2. concentrationthe filtrate was concentrated on a rotary evaporator
3. customThe crude product was purified by preparative HPLC (Method 20)
4. customfreed from the solvent on a rotary evaporator
5. customDrying in an HV