反应详情

温度

80 °C

2-{[6-{3-[3,5-Bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl}-4-(trifluoro-methyl)pyridin-3-yl]methyl}-1H-isoindole-1,3(2H)-dione (0.31 g) and hydrazine hydrate (0.035 ml) were added to ethanol (5 ml), and heated at 80° C. for 5 hours. The solvent was distilled off under reduced pressure, and then t-butyl methyl ether was added. The undissolved matters were removed by filtration, and the target compound (0.24 g) was obtained after concentration under reduced pressure.

1. distillationThe solvent was distilled off under reduced pressure
2. additiont-butyl methyl ether was added
3. customThe undissolved matters were removed by filtration