反应详情

温度

0 °C

N-{[6-{3-[3,5-Bis(trifluoromethyl)phenyl]-3-(trifluoromethyl)pyrrolidin-1-yl-}-4-(trifluoro-methyl)pyridin-3-yl]methyl}cyclopropanecarboxamide (0.15 g) was dissolved in acetonitrile (3 ml) and to the solution was added cerium ammonium nitrate (IV) (1 M aqueous solution, 0.51 ml) at 0° C. After stirring at 0° C. for 3 hours, an aqueous solution of sodium sulfite was added, extracted with ethyl acetate, dried over magnesium sulfate, filtered and concentrated. The target compound (0.12 g) was obtained by purification with silica gel column chromatography.

1. extractionextracted with ethyl acetate
2. dry with materialdried over magnesium sulfate
3. filtrationfiltered
4. concentrationconcentrated