Hydrochloric Acid → HCID 68646783, compound

HRID 220696Notes

Reaction equation

HRID 220696 reaction equation
[CH2:1]([NH:3][C:4](=[O:26])[O:5][CH2:6][CH:7]([NH:18]C(OC(C)(C)C)=O)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]([F:17])([F:16])[F:15])[CH3:2].[ClH:27]>O1CCOCC1>[ClH:27].[CH2:1]([NH:3][C:4](=[O:26])[O:5][CH2:6][CH:7]([NH2:18])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[C:14]([F:15])([F:16])[F:17])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59536818HCID 59536818, compound

Product 1

HCID 68646783HCID 68646783, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Of the compound from Example 186A, 345 mg (0.92 mmol) were admixed with 10 ml of a 4N solution of hydrogen chloride in dioxane, and the mixture was stirred at RT for 30 min. All volatile constituents were then removed on a rotary evaporator. The residue (311 mg, 100% of theory) was the title compound.

Workup

  1. customAll volatile constituents were then removed on a rotary evaporator

Sources & evidence

ORD record
ord-3c9ff88465104171b40f2c9590dd53aa
Source dataset
uspto-grants-2012_06
Patent number
US08202895B2

Reaction notes

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