Pyrazinemethanol → Pyrazin-2-ylmethyl methanesulfonate

HRID 2207022Notes

Reaction equation

[CH3:1][S:2]([O:5][CH2:6][C:7]1[CH:8]=[N:9][CH:10]=NC=1)(=[O:4])=[O:3].[N:13]1C=CN=C[C:14]=1CO>>[CH3:1][S:2]([O:5][CH2:6][C:7]1[CH:8]=[N:9][CH:10]=[CH:14][N:13]=1)(=[O:3])=[O:4]

Participants

Reactant 2

HCID 201734Pyrazinemethanol

HCID 86610239Methanesulfonic acid pyrimidin-5-ylmethyl ester

Product 1

HCID 15096999Pyrazin-2-ylmethyl methanesulfonate

Procedure

Pyrazin-2-ylmethyl methanesulfonate was prepared in a similar manner as used to prepare pyrimidin-5-ylmethyl methanesulfonate using pyrazin-2-ylmethanol instead of pyrimidin-5-ylmethanol. LCMS-ESI+ (m/z): [M+H]+ calc'd for C6H8N2O3S: 189.03; found: 189.01.

Sources & evidence

ORD record: ord-c002239bd8a647cbb22c35e234e26b1b
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09376392B2

Reaction notes

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