反应详情

To a stirred solution of 2,7-dimethylquinolin-6-ol (200 mg, 1.2 mmol) in acetic acid (10 mL) was added Br2 (0.062 mL, 1.21 mmol) at ambient temperature. The mixture was stirred at ambient temperature for 0.5 hour. The solid formed was filtered and collected, washed with 2 mL of acetic acid to give 5-bromo-2,7-dimethylquinolin-6-ol as an HBr salt. LCMS-ESI+ (m/z): [M+H]+ calc'd for C11H11BrNO: 251.99; Found: 252.2, 254.2.

1. customThe solid formed
2. filtrationwas filtered
3. customcollected
4. washwashed with 2 mL of acetic acid