反应详情

AD-mix-α (8 g, excess) was added to a mixed solvent of t-butanol and water (35 mL/35 mL) and stirred at room temperature for 5 min, cooled to 0° C. 5-bromo-2,7-dimethyl-6-vinylquinoline (678 mg, 2.6 mmol) was added and the mixture was stirred at 0° C. for 16 hrs. The mixture was diluted with ethyl acetate, washed with NaHCO3 solution, water and brine, and dried over Na2SO4. Concentration and purification by flash column chromatography yielded (S)-1-(5-bromo-2,7-dimethylquinolin-6-yl)ethane-1,2-diol. LCMS-ESI+ (m/z): [M+H]+ calc'd for C13H15BrNO2: 296.0; Found: 296.1.

1. temperaturecooled to 0° C
2. stirringthe mixture was stirred at 0° C. for 16 hrs
3. washwashed with NaHCO3 solution, water and brine
4. dry with materialdried over Na2SO4
5. concentrationConcentration and purification by flash column chromatography