Potassium Iodide → ETHYL 2-[(2,2,2-TRIFLUOROETHYL)AMINO]ACETATE(WXC09054)

2,2,2-trifluoroethylamine (2.0 g) was added to a suspension of ethyl bromoacetate (2.3 mL), potassium iodide (0.34 g) in diisopropylethylamine (3.3 mL) and the mixture was stirred at RT for 5.5 h. The mixture was diluted with diethyl ether (30 mL), stirred at RT for 30 mins. The suspension was filtered and concentrated under reduced pressure. The sub-title compound (2.6 g) was obtained as a yellow oil; 1H NMR (300 MHz, CDCl3); 4.19 (2H, q), 3.50 (2H, s), 3.22 (2H, q), 1.26 (3H, t).

1. stirringstirred at RT for 30 mins
2. filtrationThe suspension was filtered
3. concentrationconcentrated under reduced pressure

ORD record

ord-276800c65e9d44e18cc9eef479b31a66

Source dataset

uspto-grants-2016_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09376398B2