Ethanamine, 2,2,2-trifluoro- → Tert-butyl 2-[(2,2,2-trifluoroethyl)amino]acetate

HRID 2207106Notes

Reaction equation

HRID 2207106 reaction equation
Br[CH2:2][C:3]([O:5][C:6]([CH3:9])([CH3:8])[CH3:7])=[O:4].[F:10][C:11]([F:15])([F:14])[CH2:12][NH2:13]>>[F:10][C:11]([F:15])([F:14])[CH2:12][NH:13][CH2:2][C:3]([O:5][C:6]([CH3:9])([CH3:8])[CH3:7])=[O:4]

Participants

3

Reactant 2

HCID 9773Ethanamine, 2,2,2-trifluoro-HCID 79177tert-Butyl bromoacetate

Product 1

HCID 60680127Tert-butyl 2-[(2,2,2-trifluoroethyl)amino]acetateYield 74%

Procedure

The subtitled compound was synthesized by the method of example 15 step (i) from tert-butyl bromoacetate (13.6 g) and 2,2,2-trifluoroethylamine (8.9 g). The sub-title compound (11 g) was obtained as a colourless oil; 1H NMR (300 MHz, CDCl3); 3.39 (2H, s), 3.20 (2H, q, J=9.4 Hz), 1.44 (9H, s).

Sources & evidence

ORD record
ord-69924a9a1754450da59d7cdbb10689cf
Source dataset
uspto-grants-2016_06
Patent number
US09376398B2

Reaction notes

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