HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanamine, 2,2,2-trifluoro- → Tert-butyl 2-[(2,2,2-trifluoroethyl)amino]acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanamine, 2,2,2-trifluoro- | HCID 9773 | — |
| Reactant | tert-Butyl bromoacetate | HCID 79177 | — |
| Product | Tert-butyl 2-[(2,2,2-trifluoroethyl)amino]acetate | HCID 60680127 | 74% |
Reaction Steps
The subtitled compound was synthesized by the method of example 15 step (i) from tert-butyl bromoacetate (13.6 g) and 2,2,2-trifluoroethylamine (8.9 g). The sub-title compound (11 g) was obtained as a colourless oil; 1H NMR (300 MHz, CDCl3); 3.39 (2H, s), 3.20 (2H, q, J=9.4 Hz), 1.44 (9H, s).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09376398B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-69924a9a1754450da59d7cdbb10689cf |
| Source note | uspto-grants-2016_06 |