Benzylamine → 4-(Benzylamino)but-3-en-2-one

HRID 2207145Notes

Reaction equation

HRID 2207145 reaction equation
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.CO[CH:11]=[CH:12][C:13](=[O:15])[CH3:14]>C(Cl)(Cl)Cl>[CH2:1]([NH:8][CH:11]=[CH:12][C:13](=[O:15])[CH3:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 942973-Buten-2-one, 4-methoxy-

Product 1

HCID 5214434-(Benzylamino)but-3-en-2-oneYield 70%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A mixture of benzylamine (1.1 mL, 10 mmol) and 4-methoxybut-3-en-2-one (1 mL, 10 mmol) in chloroform (100 mL) was stirred at room temperature until complete conversion. Then, the solvent was evaporated to afford the desired product 30 in 70% yield which was used without additional purification.

Workup

  1. customThen, the solvent was evaporated

Sources & evidence

ORD record
ord-6983509c973240aca8c91fe06bd0f612
Source dataset
uspto-grants-2016_06
Patent number
US09376387B2

Reaction notes

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