2-Chlorobenzylamine → HCID 131735879, compound

HRID 2207153Notes

Reaction equation

HRID 2207153 reaction equation
CO[CH:3]=[CH:4][C:5](=[O:7])[CH3:6].[Cl:8][C:9]1[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=1[CH2:11][NH2:12]>C(Cl)Cl>[Cl:8][C:9]1[CH:16]=[CH:15][CH:14]=[CH:13][C:10]=1[CH2:11][NH:12][CH:3]=[CH:4][C:5](=[O:7])[CH3:6]

Participants

4

Reactant 2

HCID 666482-ChlorobenzylamineHCID 942973-Buten-2-one, 4-methoxy-

Product 1

HCID 131735879HCID 131735879, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of 4-methoxy-3-buten-2-one (100.1 mg, 1 mmol) and 2-chlorobenzylamine (141.6 mg, 1 mmol) in dry CH2Cl2 (5 mL) is stirred under reflux for 2 h. The solvent is evaporated under reduced pressure to afford the title compound 45 as a yellow oil (Yield 209 mg, 100%).

Workup

  1. temperatureunder reflux for 2 h
  2. customThe solvent is evaporated under reduced pressure

Sources & evidence

ORD record
ord-3a4a2ce75550446d87ae63d6a7fffe13
Source dataset
uspto-grants-2016_06
Patent number
US09376387B2

Reaction notes

Loading…