HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → methyl 1-benzyl-4-[2-(6-methoxy-1-oxo-3,4-dihydroisoquinolin-2-yl)ethyl]-2-methyl-4H-pyridine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | Methyl acetoacetate | HCID 7757 | — |
| Reactant | Ceric ammonium nitrate | HCID 180504 | — |
| Reactant | 6-Methoxy-1-oxo-3,4-dihydroisoquinolin-2-ylpent-2-enal | HCID 131735880 | — |
| Product | methyl 1-benzyl-4-[2-(6-methoxy-1-oxo-3,4-dihydroisoquinolin-2-yl)ethyl]-2-methyl-4H-pyridine-3-carboxylate | HCID 118558013 | — |
Reaction Steps
The title compound 48 is prepared according to the procedure reported in Example 13 with aldehyde 50 (50 mg, 0.19 mmol), benzylamine (20.6 mg, 1 equiv), methyl acetoacetate (22.4 mg, 1 equiv) and CAN (5.2 mg, 5 mol %) as reactants in MeOH. (Yield 18.9 mg, 21%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09376387B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-e5d030d97bc54b9b865c05cf7f487615 |
| Source note | uspto-grants-2016_06 |