HRID2207157

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID887

Methanol

CH4O

HCID7504

Benzylamine

C7H9N

HCID7757

Methyl acetoacetate

C5H8O3

结构：O=[N+]([O-])[O-].O=[N+]([O-])[O-].O=[N+]([O-])[O-].O=[N+]([O-])[O-].O=[N+]([O-])[O-].O=[N+]([O-])[O-].[Ce+4].[NH4+].[NH4+]

HCID180504

未命名化合物

HCID131735880

未命名化合物

PRODUCTS

生成物

结构：COC(=O)C1=C(C)N(Cc2ccccc2)C=CC1CCN1CCc2cc(OC)ccc2C1=O

HCID118558013

未命名化合物

PROCEDURE

实验过程

The title compound 48 is prepared according to the procedure reported in Example 13 with aldehyde 50 (50 mg, 0.19 mmol), benzylamine (20.6 mg, 1 equiv), methyl acetoacetate (22.4 mg, 1 equiv) and CAN (5.2 mg, 5 mol %) as reactants in MeOH. (Yield 18.9 mg, 21%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-e5d030d97bc54b9b865c05cf7f487615
来源数据集: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09376387B2
来源说明: uspto-grants-2016_06

反应 SMILES

[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[N:8]([C:14](=[CH:17][CH2:18][CH3:19])C=O)[CH2:7][CH2:6]2.[CH2:20]([NH2:27])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.[C:28]([O:34][CH3:35])(=[O:33])[CH2:29][C:30]([CH3:32])=O.O=[N+]([O-])[O-].[O-][N+](=O)[O-].[O-][N+](=O)[O-].[O-][N+](=O)[O-].[O-][N+](=O)[O-].[O-][N+](=O)[O-].[Ce+4].[NH4+].[NH4+].[CH3:63]O>>[CH2:20]([N:27]1[CH:63]=[CH:19][CH:18]([CH2:17][CH2:14][N:8]2[CH2:7][CH2:6][C:5]3[C:10](=[CH:11][CH:12]=[C:3]([O:2][CH3:1])[CH:4]=3)[C:9]2=[O:13])[C:29]([C:28]([O:34][CH3:35])=[O:33])=[C:30]1[CH3:32])[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1