HuagongsheHuagongshe Chemistry Print Report · For research reference only
Crotonaldehyde → (E)-4-(6-methoxy-1-oxo-tetralin-2-yl)but-2-enal
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Crotonaldehyde | HCID 447466 | — |
| Reactant | 2-Allyl-6-methoxy-tetralin-1-one | HCID 18794575 | — |
| Product | (E)-4-(6-methoxy-1-oxo-tetralin-2-yl)but-2-enal | HCID 90303875 | — |
Reaction Steps
The title compound 54 is prepared according to the procedure reported in step C of Example 8 with tetralone 53 (1.1 g, 5.09 mmol) and crotonaldehyde (1.43 g, 20.34 mmol) as reactants. Purification by column chromatography on SiO2 (Petroleum/EtOAc=4:1) afford the title compound 54 as an off-white solid. (Yield 0.95 g, 76%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09376387B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-6505fdf0067f4618b7ac29437f715ab2 |
| Source note | uspto-grants-2016_06 |