HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluorobenzylamine → 4-[(2-Fluorophenyl)methylamino]but-3-en-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluorobenzylamine | HCID 66649 | — |
| Reactant | 3-Buten-2-one, 4-methoxy- | HCID 94297 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-[(2-Fluorophenyl)methylamino]but-3-en-2-one | HCID 131735881 | 100% |
Reaction Steps
A solution of 4-methoxy-3-buten-2-one (0.1 g, 1 mmol) and 2-fluorobenzylamine (0.125 g, 1 mmol) in dry CH2Cl2 (5 mL) is stirred under reflux for 2 h. The solvent is evaporated under pressure to afford the title compound 56 as a yellow oil (Yield 0.19 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09376387B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-a3eef30475214ec299ac679ed5a1940b |
| Source note | uspto-grants-2016_06 |