Benzenemethanamine, 3-chloro- → 4-[(3-Chlorophenyl)methylamino]but-3-en-2-one

HRID 2207169Notes

Reaction equation

HRID 2207169 reaction equation
CO[CH:3]=[CH:4][C:5](=[O:7])[CH3:6].[Cl:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=1)[CH2:12][NH2:13]>>[Cl:8][C:9]1[CH:10]=[C:11]([CH2:12][NH:13][CH:3]=[CH:4][C:5](=[O:7])[CH3:6])[CH:14]=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 77802Benzenemethanamine, 3-chloro-HCID 942973-Buten-2-one, 4-methoxy-

Product 1

HCID 1317358824-[(3-Chlorophenyl)methylamino]but-3-en-2-one

Procedure

The title compound 64 is prepared according to the procedure reported in step A of Example 18 with 4-methoxy-3-buten-2-one (0.1 g, 1 mmol) and 3-chlorobenzylamine (0.138 g, 1 mmol) as reactants. Yellow oil. (Yield 0.21 g, 100%).

Sources & evidence

ORD record
ord-92e4cc37b1c94880b485f31b6e8d8d9a
Source dataset
uspto-grants-2016_06
Patent number
US09376387B2

Reaction notes

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