3-(Trifluoromethyl)benzylamine → 4-[[3-(Trifluoromethyl)phenyl]methylamino]but-3-en-2-one

HRID 2207171Notes

Reaction equation

HRID 2207171 reaction equation
CO[CH:3]=[CH:4][C:5](=[O:7])[CH3:6].[F:8][C:9]([F:19])([F:18])[C:10]1[CH:11]=[C:12]([CH:15]=[CH:16][CH:17]=1)[CH2:13][NH2:14]>>[F:8][C:9]([F:18])([F:19])[C:10]1[CH:11]=[C:12]([CH2:13][NH:14][CH:3]=[CH:4][C:5](=[O:7])[CH3:6])[CH:15]=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 759623-(Trifluoromethyl)benzylamineHCID 942973-Buten-2-one, 4-methoxy-

Product 1

HCID 1317358834-[[3-(Trifluoromethyl)phenyl]methylamino]but-3-en-2-one

Procedure

The title compound 66 is prepared according to the procedure reported in step A of Example 18 with 4-methoxy-3-buten-2-one (0.2 g, 2 mmol) and 3-trifluoromethylbenzylamine (0.35 g, 2 mmol) as reactants. Yellow oil. (Yield 0.48 g, 100%).

Sources & evidence

ORD record
ord-68fe74477521486bb86219ed14a507ae
Source dataset
uspto-grants-2016_06
Patent number
US09376387B2

Reaction notes

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