Crotonaldehyde → HCID 90304014, compound

HRID 2207177Notes

Reaction equation

HRID 2207177 reaction equation
[CH2:1]([CH:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[C:10]([O:15][CH3:16])[CH:11]=2)[C:6]1=[O:17])[CH2:2][CH:3]=[CH2:4].[CH:18](=[O:22])/C=C/C>>[CH3:16][O:15][C:10]1[CH:11]=[C:12]2[C:7](=[CH:8][CH:9]=1)[C:6](=[O:17])[CH:5]([CH2:1][CH2:2]/[CH:3]=[CH:4]/[CH:18]=[O:22])[CH2:14][CH2:13]2

Participants

3

Reactant 2

HCID 447466CrotonaldehydeHCID 90303965HCID 90303965, compound

Product 1

HCID 90304014HCID 90304014, compound

Procedure

The title compound 76 is prepared according to the procedure reported in step C of Example 8 with tetralone 75 (130 mg, 0.56 mmol) and crotonaldehyde (0.19 mL, 2.24 mmol) as reactants. Purification by column chromatography on SiO2 (Petroleum/diethyl ether=1:1) afford the title compound 76 as an off-white solid. (Yield 121 mg, 83%).

Workup

  1. customThe title compound 76 is prepared
  2. customPurification by column chromatography on SiO2 (Petroleum/diethyl ether=1:1)

Sources & evidence

ORD record
ord-ece5c96b6fd24e7181d2dc35ca566e3f
Source dataset
uspto-grants-2016_06
Patent number
US09376387B2

Reaction notes

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