Allyl bromide → HCID 11195631, compound

HRID 2207179Notes

Reaction equation

HRID 2207179 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C:8](=[O:14])[CH2:7][CH2:6]2.[CH2:15](Br)[CH:16]=[CH2:17]>>[CH2:17]([CH:7]1[CH2:6][C:5]2[C:9](=[CH:10][C:11]([O:12][CH3:13])=[C:3]([O:2][CH3:1])[CH:4]=2)[C:8]1=[O:14])[CH:16]=[CH2:15]

Participants

3

Reactant 2

HCID 7841Allyl bromideHCID 750185,6-Dimethoxy-1-indanone

Product 1

HCID 11195631HCID 11195631, compound

Procedure

The title compound 78 is prepared according to the procedure reported in step A of Example 17 with 5,6-dimethoxy-1-indanone (1 g, 5.2 mmol) and allyl bromide (0.86 mL, 7.17 mmol) as reactants. Purification by column chromatography on SiO2 (Petroleum Ether/EtOAc=2:1) afford the title compound 78 as a colorless oil. (Yield 0.5 g, 46%).

Workup

  1. customThe title compound 78 is prepared
  2. customPurification by column chromatography on SiO2 (Petroleum Ether/EtOAc=2:1)

Sources & evidence

ORD record
ord-8b2a29bd008f469eacb2f7990b538d9b
Source dataset
uspto-grants-2016_06
Patent number
US09376387B2

Reaction notes

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