Crotonaldehyde → HCID 118557933, compound

HRID 2207180Notes

Reaction equation

HRID 2207180 reaction equation
[CH2:1]([CH:4]1[CH2:12][C:11]2[C:6](=[CH:7][C:8]([O:15][CH3:16])=[C:9]([O:13][CH3:14])[CH:10]=2)[C:5]1=[O:17])[CH:2]=[CH2:3].[CH:18](=[O:22])/C=C/C>>[CH3:14][O:13][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][C:8]=1[O:15][CH3:16])[C:5](=[O:17])[CH:4]([CH2:1]/[CH:2]=[CH:3]/[CH:18]=[O:22])[CH2:12]2

Participants

3

Reactant 2

HCID 447466CrotonaldehydeHCID 11195631HCID 11195631, compound

Product 1

HCID 118557933HCID 118557933, compound

Procedure

The title compound 79 is prepared according to the procedure reported in step C of Example 8 with indanone 78 (0.5 g, 2.1 mmol) and crotonaldehyde (0.75 mL) as reactants. Purification by column chromatography on SiO2 (Petroleum Ether/EtOAc=1:1) afford the title compound 79 as a white solid. (Yield 0.5 g, 91%).

Workup

  1. customThe title compound 79 is prepared
  2. customPurification by column chromatography on SiO2 (Petroleum Ether/EtOAc=1:1)

Sources & evidence

ORD record
ord-fe633c3e3c484854ba5aca2e20788486
Source dataset
uspto-grants-2016_06
Patent number
US09376387B2

Reaction notes

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