Benzylamine → HCID 118557977, compound

HRID 2207182Notes

Reaction equation

HRID 2207182 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[C:9](=[O:13])[CH:8]([CH2:14]/[CH:15]=[CH:16]/[CH:17]=O)[CH2:7][CH2:6]2.[CH3:19][S:20]([CH2:23][C:24](=O)[CH3:25])(=[O:22])=[O:21].[CH2:27]([NH2:34])[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[CH2:27]([N:34]1[CH:17]=[CH:16][CH:15]([CH2:14][CH:8]2[CH2:7][CH2:6][C:5]3[C:10](=[CH:11][CH:12]=[C:3]([O:2][CH3:1])[CH:4]=3)[C:9]2=[O:13])[C:23]([S:20]([CH3:19])(=[O:22])=[O:21])=[C:24]1[CH3:25])[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1

Participants

4

Reactant 3

HCID 7504BenzylamineHCID 786951-(Methylsulphonyl)acetoneHCID 90303875(E)-4-(6-methoxy-1-oxo-tetralin-2-yl)but-2-enal

Product 1

HCID 118557977HCID 118557977, compound

Procedure

The title compound 81 is prepared according to the procedure reported in Example 27 with aldehyde 54 (60.9 mg, 0.25 mmol), commercial 1-methylsulfonylpropan-2-one (34.0 mg, 0.25 mmol) and benzylamine (26.8 mg, 0.25 mmol) as reactants. Purification by column chromatography on SiO2 (gradient of EtOAc in Petroleum Ether) afford the title compound 81 as a pale yellow solid. (Yield 32.8 mg, 29%).

Workup

  1. customThe title compound 81 is prepared
  2. customPurification by column chromatography on SiO2 (gradient of EtOAc in Petroleum Ether)

Sources & evidence

ORD record
ord-9e23757ec510427ab0569704bbbd55d2
Source dataset
uspto-grants-2016_06
Patent number
US09376387B2

Reaction notes

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