HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → HCID 118557977, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | 1-(Methylsulphonyl)acetone | HCID 78695 | — |
| Reactant | (E)-4-(6-methoxy-1-oxo-tetralin-2-yl)but-2-enal | HCID 90303875 | — |
| Product | HCID 118557977 | HCID 118557977 | — |
Reaction Steps
The title compound 81 is prepared according to the procedure reported in Example 27 with aldehyde 54 (60.9 mg, 0.25 mmol), commercial 1-methylsulfonylpropan-2-one (34.0 mg, 0.25 mmol) and benzylamine (26.8 mg, 0.25 mmol) as reactants. Purification by column chromatography on SiO2 (gradient of EtOAc in Petroleum Ether) afford the title compound 81 as a pale yellow solid. (Yield 32.8 mg, 29%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09376387B2 |
| Source dataset | uspto-grants-2016_06 |
| ORD ID | ord-9e23757ec510427ab0569704bbbd55d2 |
| Source note | uspto-grants-2016_06 |