Stannane, tributyl(1-ethoxyethenyl)- → 2-[(3-Acetyl-4-pyridyl)methyl]-6,7-dimethoxy-tetralin-1-one

HRID 2207199Notes

Reaction equation

HRID 2207199 reaction equation
Br[C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[CH2:8][CH:9]1[CH2:18][CH2:17][C:16]2[C:11](=[CH:12][C:13]([O:21][CH3:22])=[C:14]([O:19][CH3:20])[CH:15]=2)[C:10]1=[O:23].[CH2:24]([O:26]C([Sn](CCCC)(CCCC)CCCC)=C)[CH3:25]>>[C:24]([C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[CH2:8][CH:9]1[CH2:18][CH2:17][C:16]2[C:11](=[CH:12][C:13]([O:21][CH3:22])=[C:14]([O:19][CH3:20])[CH:15]=2)[C:10]1=[O:23])(=[O:26])[CH3:25]

Participants

3

Reactant 2

HCID 619414Stannane, tributyl(1-ethoxyethenyl)-HCID 1185578592-[(3-Bromo-4-pyridyl)methyl]-6,7-dimethoxy-tetralin-1-one

Product 1

HCID 1185580212-[(3-Acetyl-4-pyridyl)methyl]-6,7-dimethoxy-tetralin-1-one

Procedure

The title compound 104 is prepared according to the procedure reported in Example 36.5 with compound 100 (175 mg, 0.47 mmol) and (l-ethoxyvinyl)tri(n-butyl)stannane (0.16 mL, 0.47 mmol) as reactants. White solid. (Yield 93.2 g, 58%).

Sources & evidence

ORD record
ord-7c7b1159ce414e74aee2b51b9f3c8cf5
Source dataset
uspto-grants-2016_06
Patent number
US09376387B2

Reaction notes

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