反应详情

Compound 99 (69.2 mg, 0.2 mmol) was dissolved in dichloromethane (2 mL). Benzyl bromide (48 μL, 0.4 mmol) was then added and the solution was heated under reflux for 12 h in a sealed tube. After concentration under reduced pressure, the solid was triturated with diethylether, filtered and washed (3×) with n-pentane to afford the title product 117 as a pale brown powder (Yield 82 mg, 80%).

1. temperaturethe solution was heated
2. temperatureunder reflux for 12 h in a sealed tube
3. concentrationAfter concentration under reduced pressure
4. customthe solid was triturated with diethylether
5. filtrationfiltered
6. washwashed (3×) with n-pentane