m-Xylyl bromide → 2-[[3-Bromo-1-(m-tolylmethyl)pyridin-1-ium-4-yl]methyl]-6-methoxy-tetralin-1-one bromide

HRID 2207208Notes

Reaction equation

HRID 2207208 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[CH:6][C:7]=1[CH2:8][CH:9]1[CH2:18][CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:19][CH3:20])[CH:15]=2)[C:10]1=[O:21].[CH3:22][C:23]1[CH:24]=[C:25]([CH:28]=[CH:29][CH:30]=1)[CH2:26]Br>>[Br-:1].[Br:1][C:2]1[CH:3]=[N+:4]([CH2:22][C:23]2[CH:24]=[C:25]([CH3:26])[CH:28]=[CH:29][CH:30]=2)[CH:5]=[CH:6][C:7]=1[CH2:8][CH:9]1[CH2:18][CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([O:19][CH3:20])[CH:15]=2)[C:10]1=[O:21]

Participants

3

Reactant 2

HCID 12099m-Xylyl bromideHCID 1185580372-[(3-Bromo-4-pyridyl)methyl]-6-methoxy-tetralin-1-one

Product 1

HCID 1185580652-[[3-Bromo-1-(m-tolylmethyl)pyridin-1-ium-4-yl]methyl]-6-methoxy-tetralin-1-one bromide

Procedure

The title compound 118 is prepared according to the procedure reported in Example 38.1 with compound 99 (67 mg, 0.2 mmol) and 3-methylbenzyl bromide as reactants. White solid. (Yield 82.5 mg, 56%).

Sources & evidence

ORD record
ord-7c52d900cb80467f9aa42fc0cc902209
Source dataset
uspto-grants-2016_06
Patent number
US09376387B2

Reaction notes

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