Benzyl Bromide → 2-[(3-Acetyl-1-benzyl-pyridin-1-ium-4-yl)methyl]-6-methoxy-tetralin-1-one bromide

HRID 2207209Notes

Reaction equation

HRID 2207209 reaction equation
[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:21][CH3:22])[CH:17]=2)[C:12]1=[O:23])(=[O:3])[CH3:2].[CH2:24]([Br:31])[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>>[Br-:31].[C:1]([C:4]1[CH:5]=[N+:6]([CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:21][CH3:22])[CH:17]=2)[C:12]1=[O:23])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 7498Benzyl BromideHCID 1185580142-[(3-Acetyl-4-pyridyl)methyl]-6-methoxy-tetralin-1-one

Product 1

HCID 1185580592-[(3-Acetyl-1-benzyl-pyridin-1-ium-4-yl)methyl]-6-methoxy-tetralin-1-one bromide

Procedure

The title compound 119 is prepared according to the procedure reported in Example 38.1 with compound 103 (67 mg, 0.2 mmol) and benzyl bromide as reactants. White solid. (Yield 34.5 mg, 80%).

Sources & evidence

ORD record
ord-f5f7ce2042d84f28ba74695e36e7b4bd
Source dataset
uspto-grants-2016_06
Patent number
US09376387B2

Reaction notes

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