m-Xylyl bromide → 2-[[3-Acetyl-1-(m-tolylmethyl)pyridin-1-ium-4-yl]methyl]-6-methoxy-tetralin-1-one bromide

HRID 2207210Notes

Reaction equation

HRID 2207210 reaction equation
[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:21][CH3:22])[CH:17]=2)[C:12]1=[O:23])(=[O:3])[CH3:2].[CH3:24][C:25]1[CH:26]=[C:27]([CH:30]=[CH:31][CH:32]=1)[CH2:28][Br:29]>>[Br-:29].[C:1]([C:4]1[CH:5]=[N+:6]([CH2:24][C:25]2[CH:26]=[C:27]([CH3:28])[CH:30]=[CH:31][CH:32]=2)[CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:21][CH3:22])[CH:17]=2)[C:12]1=[O:23])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 12099m-Xylyl bromideHCID 1185580142-[(3-Acetyl-4-pyridyl)methyl]-6-methoxy-tetralin-1-one

Product 1

HCID 1185579242-[[3-Acetyl-1-(m-tolylmethyl)pyridin-1-ium-4-yl]methyl]-6-methoxy-tetralin-1-one bromide

Procedure

The title compound 120 is prepared according to the procedure reported in Example 38.1 with compound 103 (62 mg, 0.2 mmol) and 3-methylbenzyl bromide (46 μL, 0.34 mmol) as reactants. White solid. (Yield 79.3 mg, 80%).

Sources & evidence

ORD record
ord-3f60ed2cffc8467fa0d6f3b16e84223a
Source dataset
uspto-grants-2016_06
Patent number
US09376387B2

Reaction notes

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