p-Xylyl bromide → 2-[[3-Acetyl-1-(p-tolylmethyl)pyridin-1-ium-4-yl]methyl]-6-methoxy-tetralin-1-one bromide

HRID 2207220Notes

Reaction equation

HRID 2207220 reaction equation
[C:1]([C:4]1[CH:5]=[N:6][CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:21][CH3:22])[CH:17]=2)[C:12]1=[O:23])(=[O:3])[CH3:2].[CH3:24][C:25]1[CH:32]=[CH:31][C:28]([CH2:29][Br:30])=[CH:27][CH:26]=1>>[Br-:30].[C:1]([C:4]1[CH:5]=[N+:6]([CH2:24][C:25]2[CH:32]=[CH:31][C:28]([CH3:29])=[CH:27][CH:26]=2)[CH:7]=[CH:8][C:9]=1[CH2:10][CH:11]1[CH2:20][CH2:19][C:18]2[C:13](=[CH:14][CH:15]=[C:16]([O:21][CH3:22])[CH:17]=2)[C:12]1=[O:23])(=[O:3])[CH3:2]

Participants

3

Reactant 2

HCID 7721p-Xylyl bromideHCID 1185580142-[(3-Acetyl-4-pyridyl)methyl]-6-methoxy-tetralin-1-one

Product 1

HCID 1185580692-[[3-Acetyl-1-(p-tolylmethyl)pyridin-1-ium-4-yl]methyl]-6-methoxy-tetralin-1-one bromide

Procedure

The title compound 130 is prepared according to the procedure reported in Example 38.1 with compound 103 (120 mg, 0.387 mmol) and 4-methylbenzyl bromide (122 mg, 0.66 mmol) as reactants. White solid. (Yield 181.7 mg, 95%).

Sources & evidence

ORD record
ord-d0625fedb9734facadb69c55e985f8c4
Source dataset
uspto-grants-2016_06
Patent number
US09376387B2

Reaction notes

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