Benzyl Bromide → HCID 118558053, compound

HRID 2207235Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][C:11]=1[O:12][CH3:13])[C:8](=[O:14])/[C:7](=[CH:15]/[C:16]1[CH:21]=[CH:20][N:19]=[CH:18][C:17]=1[C:22]([NH:24][CH3:25])=[O:23])/[CH2:6]2.[CH2:26]([Br:33])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[Br-:33].[CH2:26]([N+:19]1[CH:20]=[CH:21][C:16](/[CH:15]=[C:7]2/[C:8](=[O:14])[C:9]3[C:5]([CH2:6]/2)=[CH:4][C:3]([O:2][CH3:1])=[C:11]([O:12][CH3:13])[CH:10]=3)=[C:17]([C:22]([NH:24][CH3:25])=[O:23])[CH:18]=1)[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

Participants

Reactant 2

HCID 7498Benzyl Bromide

HCID 118557962HCID 118557962, compound

Product 1

HCID 118558053HCID 118558053, compound

Procedure

The title compound 151 is prepared according to the procedure reported in Example 38.1 with compound 98 (50 mg, 0.148 mmol) and benzyl bromide (36 μL, 2 equiv) as reactants. Pale yellow solid. (Yield 55.2 mg, 87%).

Sources & evidence

ORD record: ord-fef33d0a963f401990becc6e2b8ffaa7
Source dataset: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09376387B2

Reaction notes

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