Benzyldihydronicotinamide → 2-[(3-acetyl-1-benzyl-4H-pyridin-4-yl)methyl]-6,7-dimethoxy-tetralin-1-one

HRID 2207245Notes

Reaction equation

HRID 2207245 reaction equation
[Br-].[C:2]([C:5]1[CH:6]=[N+:7]([CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:8]=[CH:9][C:10]=1[CH2:11][CH:12]1[CH2:21][CH2:20][C:19]2[C:14](=[CH:15][C:16]([O:24][CH3:25])=[C:17]([O:22][CH3:23])[CH:18]=2)[C:13]1=[O:26])(=[O:4])[CH3:3].C1C(C(N)=O)=CN(CC2C=CC=CC=2)C=C1>>[C:2]([C:5]1[CH:10]([CH2:11][CH:12]2[CH2:21][CH2:20][C:19]3[C:14](=[CH:15][C:16]([O:24][CH3:25])=[C:17]([O:22][CH3:23])[CH:18]=3)[C:13]2=[O:26])[CH:9]=[CH:8][N:7]([CH2:27][C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH:6]=1)(=[O:4])[CH3:3]

Participants

3

Reactant 2

HCID 95276BenzyldihydronicotinamideHCID 1317358842-[(3-Actyl-1-benzyl-pyridin-1-ium-4-yl)methyl]-6,7-dimethoxy-tetralin-1-one bromide

Product 1

HCID 1185577912-[(3-acetyl-1-benzyl-4H-pyridin-4-yl)methyl]-6,7-dimethoxy-tetralin-1-one

Procedure

The title compound 162 is prepared according to the procedure reported in Example 39.1 with compound 132 (51 mg, 0.1 mmol) and BNAH (21.4 mg, 1 equiv) as reactants. Yellow solid. (Yield 20.3 mg, 50%).

Sources & evidence

ORD record
ord-aa0c71f793ca4b798004eb3298bc6dfa
Source dataset
uspto-grants-2016_06
Patent number
US09376387B2

Reaction notes

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