反应详情

温度

120 °C

Morpholine (2.53 mL, 28.1 mmol) was added to a solution of 1-fluoro-3-iodo-5-nitrobenzene (3 g, 11.2 mmol) in DMSO (22.5 mL) under nitrogen. The reaction was heated at 120° C. for 2 hours, then cooled to room temperature and diluted with a mixture of ether and ethyl acetate. The organic layer was washed with water (2×) and concentrated under reduced pressure. The residue was purified by silica gel chromatography (ethyl acetate:hexanes) to afford 4-(3-iodo-5-nitrophenyl)morpholine as deep yellow solid.

1. temperaturecooled to room temperature
2. washThe organic layer was washed with water (2×)
3. concentrationconcentrated under reduced pressure
4. customThe residue was purified by silica gel chromatography (ethyl acetate:hexanes)