反应详情

温度

110 °C

3-Amino-5-(dihydroxyboranyl)benzoic acid (205 mg, 1.13 mmol) was added to a solution of 2-chloro-4-(trifluoromethyl)pyrimidine (203 mg, 1.11 mmol) in dioxane (3.00 mL). Methanesulfonic acid (70.0 μL, 1.08 mmol) was added to the reaction mixture and heated to reflux at 110° C. overnight. The reaction mixture was cooled to room temperature and the crude mixture was directly purified by reverse HPLC to afford 3-(dihydroxyboranyl)-5-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}benzoic acid. MS APCI C12H10BF3N3O4 [M+H]328. found 328.

1. temperatureheated
2. temperatureThe reaction mixture was cooled to room temperature
3. customthe crude mixture was directly purified by reverse HPLC