HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dichloroethane → 3-Methyl-N-[5'-(pyridin-3-yl)-2'-methyl-biphenyl-4-yl]-isonicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | 3-Methyl-isonicotinic acid | HCID 1502003 | — |
| Reactant | HCID 58683777 | HCID 58683777 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Methyl-N-[5'-(pyridin-3-yl)-2'-methyl-biphenyl-4-yl]-isonicotinamide | HCID 11588972 | 88% |
Reaction Steps
Amide Coupling Reaction: To a solution of 2′-methyl-5′-(pyridin-3-yl)biphenyl-4-amine n (40 mg, 0.15 mmol) in DCM (3 mL) was added EDC (85 mg, 0.45 mmol) and 3-methylisonicotinic acid (40 mg, 0.3 mmol). The solution was stirred at room temperature for 6 hr before it was concentrated and chromatographied to give Compound 20 (50 mg, 88%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08202999B2 |
| Source dataset | uspto-grants-2012_06 |
| ORD ID | ord-5c55252fea5048a0b18958b4ccbb0a6b |
| Source note | uspto-grants-2012_06 |