Hydrochloric Acid → HCID 89648912, compound

HRID 2207608Notes

Reaction equation

HRID 2207608 reaction equation
[CH3:1][C:2]1([CH3:16])[NH:6][C:5](=[O:7])[CH:4]([NH:8]C(=O)OC(C)(C)C)[CH2:3]1.[ClH:17].O1CCOCC1>C(Cl)Cl>[ClH:17].[NH2:8][CH:4]1[CH2:3][C:2]([CH3:16])([CH3:1])[NH:6][C:5]1=[O:7]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 89649568HCID 89649568, compound

Product 1

HCID 89648912HCID 89648912, compoundYield 97.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl N-(5,5-dimethyl-2-oxo-pyrrolidin-3-yl)carbamate (which may be prepared as described in Description 28) (1307 mg, 5.73 mmol) in DCM (5 mL) was added 4 M HCl in dioxane (2.86 mL, 11.45 mmol). The solution (which immediately started to evolve gas) was stirred at room temperature over 1 hour. The reaction mixture heavily precipitated. It was diluted with ether (approximately 50 mL) and the solid filtered under vacuum, washed with ether and dried in the vacuum oven to afford 3-amino-5,5-dimethyl-pyrrolidin-2-one hydrochloride (917 mg, 5.5701 mmol, 97.3% yield) as a white solid;

Workup

  1. customThe reaction mixture heavily precipitated
  2. additionIt was diluted with ether (approximately 50 mL)
  3. filtrationthe solid filtered under vacuum
  4. washwashed with ether
  5. customdried in the vacuum oven

Sources & evidence

ORD record
ord-cc827bf4894d48c9896a73ecb8019599
Source dataset
uspto-grants-2016_06
Patent number
US09376436B2

Reaction notes

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