HCID 89649674, compound → HCID 89649543, compound

HRID 2207626Notes

Reaction equation

HRID 2207626 reaction equation
C([O:8][C:9]1[CH:14]=[C:13]([O:15][CH2:16][CH3:17])[CH:12]=[C:11]([F:18])[C:10]=1[F:19])C1C=CC=CC=1>CO.[Pd]>[CH2:16]([O:15][C:13]1[CH:12]=[C:11]([F:18])[C:10]([F:19])=[C:9]([OH:8])[CH:14]=1)[CH3:17]

Participants

4

Reactant 1

HCID 89649674HCID 89649674, compound

Product 1

HCID 89649543HCID 89649543, compoundYield 74.9%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 1-benzyloxy-5-ethoxy-2,3-difluoro-benzene (which may be prepared as described in Description 60) (546 mg, 2.07 mmol) in methanol (10 mL) was passed through a 10% Pd—C H-cube cartridge at 1 ml/min. The solution was passed through the H-cube a second time. Chromatography on silica (elution with DCM) gave 5-ethoxy-2,3-difluoro-phenol (D61) (270 mg);

Sources & evidence

ORD record
ord-751c393c3fcd47ec8bdb27f85f86d454
Source dataset
uspto-grants-2016_06
Patent number
US09376436B2

Reaction notes

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