HCID 89649591, compound → HCID 89649112, compound

HRID 2207629Notes

Reaction equation

HRID 2207629 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([N:16]2[CH:20]=[CH:19][C:18]([CH3:21])=[N:17]2)[CH:12]=[CH:13][C:14]=1[F:15])C1C=CC=CC=1>CO.[Pd]>[F:15][C:14]1[CH:13]=[CH:12][C:11]([N:16]2[CH:20]=[CH:19][C:18]([CH3:21])=[N:17]2)=[CH:10][C:9]=1[OH:8]

Participants

4

Reactant 1

HCID 89649591HCID 89649591, compound

Product 1

HCID 89649112HCID 89649112, compoundYield 85.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 1-(3-benzyloxy-4-fluoro-phenyl)-3-methyl-pyrazole (which may be prepared as described in Description 66) (470 mg, 1.66 mmol) in methanol (20 mL) was hydrogenated using an H-Cube with 10% Pd/C (30 mm cartridge) at 50° C. and 1 mL/min flow rate. The eluent was concentrated in vacuo to give 2-fluoro-5-(3-methylpyrazol-1-yl)phenol (D68) (288 mg, 1.4236 mmol, 85.5% yield) as a colourless oil;

Workup

  1. customat 50° C.
  2. concentrationThe eluent was concentrated in vacuo

Sources & evidence

ORD record
ord-68f93297eb8e4a7c9d4caa8630a000da
Source dataset
uspto-grants-2016_06
Patent number
US09376436B2

Reaction notes

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