HCID 89649591, compound → HCID 89649112, compound

Participants

Reaction Steps

A solution of 1-(3-benzyloxy-4-fluoro-phenyl)-3-methyl-pyrazole (which may be prepared as described in Description 66) (470 mg, 1.66 mmol) in methanol (20 mL) was hydrogenated using an H-Cube with 10% Pd/C (30 mm cartridge) at 50° C. and 1 mL/min flow rate. The eluent was concentrated in vacuo to give 2-fluoro-5-(3-methylpyrazol-1-yl)phenol (D68) (288 mg, 1.4236 mmol, 85.5% yield) as a colourless oil;

Provenance & Evidence