HCID 89648808, compound → HCID 89649474, compound

HRID 2207632Notes

Reaction equation

HRID 2207632 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([N:16]2[CH:20]=[CH:19][CH:18]=[N:17]2)[CH:12]=[CH:13][C:14]=1[F:15])C1C=CC=CC=1>CO.[Pd]>[F:15][C:14]1[CH:13]=[CH:12][C:11]([N:16]2[CH:20]=[CH:19][CH:18]=[N:17]2)=[CH:10][C:9]=1[OH:8]

Participants

4

Reactant 1

HCID 89648808HCID 89648808, compound

Product 1

HCID 89649474HCID 89649474, compoundYield 77.7%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A solution of 1-(3-benzyloxy-4-fluoro-phenyl)pyrazole (which may be prepared as described in Description 71) (649.1 mg, 2.42 mmol) in methanol (20 mL) was hydrogenated through an H-Cube 10% Pd/C (70 mm cartridge) at 50° C. at a flow rate of 1 ml/minute. The eluent was collected and concentrated in vacuo to give 2-fluoro-5-pyrazol-1-yl-phenol (D72) (352.5 mg, 1.8796 mmol, 77.7% yield) as a colourless oil;

Workup

  1. customThe eluent was collected
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-1c694764d2fa4329954f2fa9ed050c67
Source dataset
uspto-grants-2016_06
Patent number
US09376436B2

Reaction notes

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