HCID 89648808, compound → HCID 89649474, compound

Participants

Reaction Steps

A solution of 1-(3-benzyloxy-4-fluoro-phenyl)pyrazole (which may be prepared as described in Description 71) (649.1 mg, 2.42 mmol) in methanol (20 mL) was hydrogenated through an H-Cube 10% Pd/C (70 mm cartridge) at 50° C. at a flow rate of 1 ml/minute. The eluent was collected and concentrated in vacuo to give 2-fluoro-5-pyrazol-1-yl-phenol (D72) (352.5 mg, 1.8796 mmol, 77.7% yield) as a colourless oil;

Provenance & Evidence