Hydrochloric Acid → HCID 86660174, compound

HRID 2207810Notes

Reaction equation

HRID 2207810 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:8]([O:13][CH:14]3[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]3)=[N:9][CH:10]=[CH:11][CH:12]=2)[CH2:3][CH2:2]1.[ClH:27]>CO>[ClH:27].[NH:17]1[CH2:16][CH2:15][CH:14]([O:13][C:8]2[C:7]([N:4]3[CH2:3][CH2:2][O:1][CH2:6][CH2:5]3)=[CH:12][CH:11]=[CH:10][N:9]=2)[CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58547921HCID 58547921, compound

Product 1

HCID 86660174HCID 86660174, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To tert-butyl 4-((3-morpholinopyridin-2-yl)oxy)piperidine-1-carboxylate (3.2 g, 8.8 mmol) was added 4 M HCl in MeOH (100 mL). The solution was stirred at room temperature for 2 hours. The solvent was removed under reduced pressure to give the title compound (2.2 g, 8.36 mmol, yield 95%). ESI-MS (M+1): 264 calc. for C14H21N3O2 263

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-7e0823376a694327a727fa8b4cd7c3e9
Source dataset
uspto-grants-2016_06
Patent number
US09376450B2

Reaction notes

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