反应详情

(1-Benzyl-2-methyl-4,5-dihydro-1H-1,3,6-triaza-benzo[e]azulen-6-yl)-phenyl-methanone from Example E5a.1 (5.73 g, 14.6 mmol) was placed in methanol (50 ml) and a 6M HCl aqueous solution (200 ml) was added. The reaction mixture was heated at reflux for 18 h then concentrated in vacuo. The residue was dissolved in dichloromethane, basified with saturated NaHCO3 then washed with brine, dried and concentrated in vacuo to yield the title compound (3.30 g, 78%).

1. temperatureThe reaction mixture was heated
2. temperatureat reflux for 18 h
3. concentrationthen concentrated in vacuo
4. dissolutionThe residue was dissolved in dichloromethane
5. washthen washed with brine
6. customdried
7. concentrationconcentrated in vacuo