Hydrochloric Acid → HCID 67477388, compound

HRID 2207850Notes

Reaction equation

HRID 2207850 reaction equation
[CH2:1]([O:8][C:9]([N:11]1[CH2:14][CH:13]([O:15][C:16]2[C:17]([C:22]3[CH2:27][CH2:26][N:25](C(OC(C)(C)C)=O)[CH2:24][CH:23]=3)=[N:18][CH:19]=[CH:20][N:21]=2)[CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:35]>C(Cl)Cl>[ClH:35].[ClH:35].[ClH:35].[Cl:35][C:22]1([C:17]2[C:16]([O:15][CH:13]3[CH2:14][N:11]([C:9]([O:8][CH2:1][C:2]4[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=4)=[O:10])[CH2:12]3)=[N:21][CH:20]=[CH:19][N:18]=2)[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58547906HCID 58547906, compound

Product 1

HCID 67477388HCID 67477388, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a stirred solution of tert-butyl 4-(3-(1-(benzyloxycarbonyl) azetidin-3-yloxy)pyrazin-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate (see PREPARATION P28.3; 0.72 g, 1.543 mmol) in DCM (5 ml) was added hydrogen chloride (3.09 mL, 12.35 mmol). The reaction mixture was stirred for 3 hours, concentrated to dryness and used in the next step. The mixture also contained 1:1 ratio of benzyl 3-((3-(1,2,3,6-tetrahydropyridin-4-yl)pyrazin-2-yl)oxy)azetidine-1-carboxylate trihydrochloride salt. MS (m+2): 404.

Workup

  1. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-7139711021bf4e059a01bb7e345fa5ce
Source dataset
uspto-grants-2016_06
Patent number
US09376450B2

Reaction notes

Loading…